Principal Investigator:Vahid Mohsenin, MD
The John B. Pierce Laboratory
Sleep apnea and intermittent hypoxia are associated with significant vascular dysfunction in the form of hypertension, myocardial infarction and stroke. Mohsenin’s research interest is to explore the mechanisms underlying endothelial and vascular dysfunction due to hypoxia-reoxygenation in the setting of obstructive sleep apnea. We have shown that sleep apnea increases the risk of stroke and death independent of known risk factors for stroke. We have demonstrated that subjects with severe sleep apnea have impaired cerebrovascular autoregulation in response to fluctuations in arterial blood pressure. In parallel with human studies we are conducting experiments on mice exposed to intermittent hypoxia to investigate the basic molecular mechanisms operative in the development of hypertension and vascular dysfunction.
The majority of Dr. Mohsenin’s current projects take place at the Yale Center for Sleep Medicine where he is currently the Director.
Mohsenin, V. Sleep apnea: Implications in cerebrovascular disease. Preventive Cardiology 2003; 6:149-154.
Yaggi, K. and V. Mohsenin. Obstructive Sleep apnea and Stroke. Lancet Neurol. 2004; 3:333-342.
D’Ambrosio, C.D., N.S. Stachenfeld, M. Pisani, and V. Mohsenin. Sleep, Breathing, and Menopause: The effect of fluctuating estrogen and progesterone on sleep and breathing in women. Gender Med. 2:238-245, 2005.
Yaggi, K.H. and V. Mohsenin. Sleep Apnea, Stroke, and Causal Inference: Public Health Implications. In: Pandi-Perumal SR, Leger D., editors. CRC Press. 2006. Sleep Disorders: Their Impact on Public Health.