The John B. Pierce Laboratory


Why is it so hard to switch to a healthy, low-calorie diet?

Research from the laboratory of Dr. Ivan de Araujo, Associate Fellow, makes significant progress toward answering this crucial question in the battle against obesity.

A major limitation of behavioral interventions for weight loss is the low appeal of low-calorie diets. Dr. de Araujo and his colleagues recently published evidence that a high fat diet can cause a deficiency in a gastrointestinal lipid messenger that is critical for producing normal dopamine release in the brain in response to food. The researchers went on to find that restoring this lipid messenger in deficient mice restored dopamine release and increased the interest of obese mice in a low-calorie liquid. Read more about this breakthrough study in their recent report published in Science and follow the links below to online reviews of the work.

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Lighting the Way to Study the Brain

Finding new technologies to visualize and quantify the firing of individual neurons and their myriad network connections is an essential goal of the new BRAIN initiative recently announced by President Obama. Dr. Vincent Pieribone, Fellow, in collaboration with Dr. Michael Nitibach and his lab at the Yale School of Medicine, have successfully shown in fruit fly that a genetically encoded fluorescent voltage-sensitive protein recently identified by Pieribone and his associates provides a many times stronger and faster signal of brain cell activity than any other available technology. Read the full published report of this exciting advance in brain science in the journal Cell:   and follow the links below to read what others are saying about the importance and implications of this breakthrough:

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